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Bioavailability comparisons in this SubQ vs IM peptide research area show that both routes achieve high absolute bioavailability (typically 85100% for most peptides), compared to oral delivery which often falls below 5% due to enzymatic degradation in the GI tract

But that entire safety dataset is three small animal studies with no formal toxicology arm, no dose escalation, no repeat dosing, no long-term follow-up, and nothing in humans

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second, SCFAs enhance insulin signaling in adipose tissue and liver via FFAR2/FFAR3 (GPR43/GPR41) receptor activation, and their deficiency directly exacerbates insulin resistance

However, the development of AOD-9604 as an anti-obesity pill was terminated in 2007 for lack of effectiveness in trials [1]