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The best way to handle this balance is for plans to document their coverage rules clearly

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Sixth, unadjusted comparisons may be subject to residual confounding, particularly for the observed sex differences

Absolute contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN2) Known hypersensitivity to the medication or its components These are based on boxed warnings and prescribing information and should be treated as non-negotiable