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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%

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Rheumatoid arthritis (RA) is a chronic inflammatory disorder that primarily affects the joints Unlike the wear-and-tear damage of osteoarthritis, RA is an autoimmune condition where the immune system mistakenly attacks the body's own tissues

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