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These findings highlight the potential importance of treatment persistence in maximizing the cardioprotective benefits of GLP-1RAs

Common adverse effects of GLP-1 receptor agonists include: Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation)usually mild to moderate and often diminishing over time Injection site reactions Headache Fatigue More serious but rare adverse effects have been identified, including: Pancreatitis patients should seek urgent medical advice for severe, persistent abdominal pain (with or without vomiting) Gallbladder disease symptoms include upper right abdominal pain and jaundice Diabetic retinopathy complications particularly with rapid HbA1c reduction in patients with pre-existing retinopathy Dehydration and acute kidney injury from persistent gastrointestinal symptoms When combined with sulfonylureas or insulin, GLP-1 receptor agonists increase the risk of hypoglycaemia

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The MHRA Early Access to Medicines Scheme (EAMS) , which allows patients with life-threatening or seriously debilitating conditions to access promising unlicensed medicines before marketing authorisation