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In the SURPASS program for type 2 diabetes, tirzepatide demonstrated A1C reductions of 2.07-2.59% across doses, with up to 97% of participants achieving A1C below 7.0%

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Although designed for non-inferiority, the SUSTAIN-6 (NCT01720446) trial showed a 2.3% reduction in MACEs in patients with T2D in patients taking weekly injectable semaglutide