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Semaglutide, originally developed to treat diabetes, acts in three major ways

10,11 Curcumin Preclinical and in vitro data suggest that curcumin can inhibit DPP-4 activity and enhance glycemic control in diabetic animal models, potentially prolonging the active life of GLP-1, although this has not been confirmed in human mechanistic studies

and [4] had at least one of the following comorbid conditions: coronary artery disease (e.g., history of myocardial infarction), cerebrovascular disease (e.g., prior stroke or transient ischemic attack), symptomatic peripheral artery disease, or chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m

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