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[DOI] [Google Scholar] Zheng R., Yan W., Xia Y

Adverse effects of CoQ10 supplementation are uncommon and mainly involve the digestive system

(2013) Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial stratified treatment of hypertension

This includes upregulation of antioxidant enzymes (superoxide dismutase, catalase) that protect against oxidative damage, enhancement of growth factor expression (TGF-, VEGF, PDGF) that supports tissue repair, and suppression of inflammatory gene expression that contributes to chronic skin degradation