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Key validation metrics include pharmacokinetics/pharmacodynamics concordance (e.g., clearance rates, area under the curve [AUC], metabolite formation), toxicological sensitivity and specificity, and the recapitulation of clinical-grade disease phenotypes and drug responses

At neomycin concentrations of 100, 200, and 400 M either inhibitor demonstrated partial attenuation of Dihexa otoprotection, indicating at least partial reliance on their associated signaling proteins for protective effects (Figure 6A)

lenta (SP5-62) and SP2-71.3 (or the entire SP2-71 pool) were present, which suggests that E

The emerging role of amino acids of the brain microenvironment in the process of metastasis formation