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Long-Term Use | Side Effects | Getting Started There is no evidence of meaningful tolerance or loss of efficacy with continued use
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IGF-1 Upregulation Downstream Anabolic Signaling Both peptides indirectly stimulate insulin-like growth factor-1 (IGF-1) production through sustained growth hormone elevation: Growth hormone binds to hepatic GH receptors activating JAK-STAT signaling pathways Increased transcription of IGF-1 gene in liver tissue Elevated plasma IGF-1 levels mediate anabolic effects in muscle, bone, and adipose tissue IGF-1 provides negative feedback regulation preventing excessive growth hormone secretion Studies report IGF-1 increases of 1.5- to 3-fold for 9-11 days following CJC-1295 administration, with the ipamorelin combination providing more sustained elevation
The usual path is to start at 3 mg once daily for about 30 days, then move up to 7 mg daily, and if needed (and tolerated), up to 14 mg
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