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Results: Evidence indicates local estrogen dominance with progesterone resistance, pervasive immune dysregulation, and oxidative stress with iron-driven ferroptosis that particularly injures granulosa cells, alongside disease-relevant genetic/epigenetic regulators and reproductive-tract/gut microbiome dysbiosis

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3 Mechanism of action of GLP-1R in lowering blood glucose GLP-1R is expressed on pancreatic -cells, -cells and -cells and reduces blood glucose levels directly or indirectly (Figure 1A)