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28 LOLA is a combination of endogenous amino acids that are metabolized in periportal and perivenous hepatocytes, where L-ornithine is utilized as a substrate in the urea cycle and acts as an activator of carbamoyl phosphate synthetase, the rate limiting enzyme of the urea cycle

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Homocysteine is an amino acid found in the bloodstream, and its excess has been linked to an increased risk of heart disease and stroke