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This review consolidates the current understanding of these individual interventions and highlights the promising, yet under-explored, potential of their combined application in CRC management

A recent metanalysis showed that FD patients treated with serotonin receptor agonists have a significantly better symptom response compared to placebo (117) and the most recently published evidence indicates efficacy for prucalopride in idiopathic gastroparesis and emerging efficacy for velusetrag in gastroparesis (118, 119)

The most advanced methods currently in clinical trials or commercially approved employ indirect targeting by immunotherapies, which focus on immune components required for MYC -driven tumors or checkpoints that are altered in MYC -driven tumors [83, 84]

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