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When you have a peptide from a different species, you may not have the peptidase, the hormone that degrades it, says Young
With retatrutide, the glucagon component increases energy expenditure, which means the total caloric deficit is larger even at similar intake levels
indeed, the overall cardiovascular safety profile remains favourable
NICE guidance provides clear recommendations for GLP-1 use, which focus exclusively on glycaemic control in type 2 diabetes (NG28) and weight management in obesity (TA875 for semaglutide, TA664 for liraglutide)
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