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The initial twice-daily formulation was discontinued due to exceptionally high rates of gastrointestinal adverse events (nausea and vomiting), leading to discontinuation rates exceeding 50% in trials

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Psychological support is also important, as lipoedema can significantly impact body image, mental health, and quality of life

This makes it an attractive drug to treat many of the cardiometabolic parameters that we are interested in. Assessing the STEPs For the four phase 3 STEP trials (Table), researchers assessed semaglutide 2.4 mg in more than 4,300 adults with obesity or overweight with a weight-related comorbid condition