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Many gastrointestinal effects are transient, but severe, persistent, or worsening symptoms should be reported to a healthcare professional

Proton magnetic resonance spectroscopy ( 1 H MRS), with its extremely high sensitivity, is used for detecting and quantifying several endogenous tissue metabolites in a single acquisition, but it is not capable of tracking the activity of a metabolic pathway due to limitations related to water, lipid suppression, and magnetic field homogeneity [22]

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This mechanistic depth is the basis for Phase 2 outcomes that exceeded all prior single- or dual-agonist research