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The carriers of CYP3A5 rs776746 A allele were overrepresented in the intentionally overdosed group and were more predisposed to acetaminophen-induced hepatotoxicity than individuals with the G allele, that rendered CYP3A5 enzyme inactive due to aberrant gene splicing [100]
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Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinsons disease by enhancing Nrf2 activity
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