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Damage to the intestinal barrier is hypothesized to allow large molecules, such as gluten and casein, to enter the bloodstream, thereby triggering the release of pro-inflammatory cytokines (e.g., IL-6 and TNF-), which may adversely affect neural function through the opioid system

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Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis