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B12 can also: Improve mood and helps retain memory and mental functions Lower fatigue and reduces muscle weakness Improve metabolism Boost sperm count Prevent or treat diabetic neuropathy, pins and needles (paraesthesia) What symptoms can occur with vitamin B12 deficiency

Polydatin modulates inflammation by decreasing NF-kappaB activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain

Endocr Rev (1992) 13:192206.10.1210/edrv-13-2-192 23 Le FournVFerrandMFrancJL