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113 The detrimental effect of autophagy induction was well demonstrated

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In addition, GLP-1RAs increase heart rate in humans, most likely via the GLP-1R located in the sinoatrial node of the heart (37) and perhaps also via activation of the sympathetic nervous system and inhibition of the parasympathetic nervous system as shown in animals studies (38, 39)

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In this trial these effects were generally mild to moderate rather than severe

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