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Irritability and Anxiety Poor sleep Gross motor problems or problems with coordination Tics Seizures (including absence seizures) If the child has untreated CFD, seizures may start at puberty Problems with vision Developmental delay and/or slowing of typical development Smaller head circumference (but certainly not always) Rett Syndrome maybe in indicator of CFD Depression *Not all these symptoms are seen in kids with CFD What Causes Cerebral Folate Deficiency

- Patients who fail to show up for their scheduled appointments without prior notice may be subject to a no-show fee

doi: 10.1093/toxsci/kfq375

Rare allergic reactions can occur with IV therapy, which is why a medical history check is mandatory

Use a portable medication cooler designed for insulin or biologicsthese maintain 28C for 2448 hours using evaporative cooling (FRIO wallets) or rechargeable Peltier cooling (brands like Lifeina or MedActiv)