is glutathione safe for long term use 9 Health Benefits of Glutathione Tablets Vs Glutathione Injections:

Yet these therapies should be viewed as adjuncts, not replacements for established treatments

Melatonins decline in aging has widespread implications weakening circadian coordination, diminishing sleep quality, lowering antioxidant defense, increasing inflammation, and reducing neuroprotection, all of which may contribute to accelerated aging and age-related diseases

10.1007/s11357-012-9419-5 Age 10 BrazoV.SantelloF.ColatoR.DuarteA.GoulartA.SampaioP.et al (2020)

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Interestingly, there have also been two case studies of hair repigmentation in men following the administration of thyroid hormone (specifically, T3)