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Little TJ, Feltrin KL, Horowitz M, Smout AJ, Rades T, Meyer JH et al

This distinction has become particularly significant in early 2026

Thats because exendin-4 was close enough in its amino-acid sequence to provide the same effects as GLP-1, yet different enough that the same enzymes that broke down GLP-1 so quickly didnt have the same effect