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While it's a good idea to check with a doctor before taking any supplement including creatine no matter how healthy or fit you are, many athletes take creatine

Vegans and Vegetarians : Individuals following plant-based diets may be at a higher risk of B12 deficiency and can benefit from B12 supplementation through injections

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The potential for gastrointestinal adverse effects, particularly nausea and vomiting, may lead to dehydration and worsening of renal function in vulnerable patients

The drugs that act on BBB integrity in the context of neurodegenerative disease warrant further investigation to understand the impact of restoring BBB integrity and protecting against breakdown