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Unexpectedly, we found that the first five amino acid residues at the N-terminus of GLP-1 and EX4 are dispensable for wild-type (WT) GLP-1R activation in both cyclic adenosine monophosphate (cAMP)/G protein signaling and arrestin-mediated pathways when they are fused to the receptor

To view or add a comment, sign in Once-Weekly Semaglutide 7.2 mg Shows Superior Weight Reduction in Obesity: Results from the STEP UP Trial Today, results from the STEP UP phase 3b trial were published in The Lancet Diabetes & Endocrinology, evaluating a higher dose of once-weekly subcutaneous semaglutide (7.2 mg) in adults with obesity but without diabetes

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