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In fact, a specific cellular signaling pathway has been described in mice, including the activation of protease-activated receptor 2 and downstream enzymes phospholipase C and protein kinases A and C by mast cell triptase, and resultant sensitization of TRPV1, TRPV4, and TRPA1 (Chen et al., 2012) observed in vitro that paclitaxel administration induced oxidative stress byproducts which ultimately activate TRPA1 and TRPV4

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In TRIUMPH-1, retatrutide was studied at target doses of 4mg, 9mg and 12mg once weekly