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The most effective eczema cream formulations for nummular eczema contain: Ceramides (an optimal ratio of 3:1:1 of ceramides:cholesterol:fatty acids has been shown to be effective in barrier repair) [21] Humectants like glycerin or hyaluronic acid Occlusives such as petrolatum or dimethicone Anti-inflammatory botanicals like colloidal oatmeal [6] Managing Treatment-Resistant Nummular Eczema When standard treatments fail after 8-12 weeks, you may be dealing with treatment-resistant nummular eczema, a significant clinical challenge [4]