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"Obesity is a chronic disease and like other chronic diseases, it may require chronic medication," Siegel says

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Future Directions and Research Priorities Emerging Therapeutic Approaches Triple agonist retatrutide and combinations including cagrisema have progressed to phase 3 trials as obesity treatments with early data suggesting even greater weight loss than tirzepatide [83]

They work by engaging the same receptors on target cells as glucagon does, triggering a cascade of different effects in our body including blood sugar regulation, insulin secretion and appetite control and potentially even immune modulation

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