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Secondary Effects of GLP-1 Agonists: Acute GI Symptoms vs Chronic Gut Microbiome Dysbiosis Some secondary effects of GLP-1 RAs are symptomatic and relatively acute, such as gastrointestinal (GI) changes (constipation, diarrhea, nausea and vomiting), therefore mitigation strategies are well known
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Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
Although the Caco-2 cell model lacks the mucus layer of the intestinal wall, lacks some metabolic enzymes, and has barrier properties that are similar to those of colonic epithelial cells but somewhat different from those of small intestinal epithelial cells [8]
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