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FIGURE 6 12 Concluding remarks and future research In summary, metabolic dysfunction in T2DM affects insulin receptor signaling, inhibiting the PI3K-Akt cascade and enhancing GSK3 hyperactivity, NAD + depletion, and Sirt1/Sirt3 inactivation

Liposomes are microscopic spheres made from phospholipids that can protect glutathione from digestive breakdown and facilitate absorption through cell membranes

The absence of a significant signal in our analysis may reflect limited statistical power or differences in allele frequency across populations, rather than a definitive lack of involvement of TMCO1 in POAG pathogenesis in non-European individuals

These diets decrease the abundance of beneficial lactic acid bacteria, crucial for maintaining intestinal health

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