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In contrast, in the Cagri-AMY 1 R-Gs structure, L119 RAMP1 is likely to clash with a rearranged imidazole side chain of H296 ECL2 that is observed when Cagri is bound to CTR and likely accounts for the different orientation of the linker in the Cagri bound AMY 1 R (Fig

10.1136/gut.2008.164418 111 TaubertD.LazarA.GrimbergG.JungN.RubbertA.DelankK

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Hypoxia has recently been shown to downregulate thiamine transporters in a colonic cell line, impairing the thiamine uptake that results in a localized intracellular deficiency (190)

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