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It may be appropriate for individuals with weight-loss resistance, insulin resistance, metabolic syndrome, PCOS, elevated cardiometabolic risk, or those who were unable to tolerate full-dose GLP-1 therapy

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[DOI] [PMC free article] [PubMed] [Google Scholar] 64.Glenny EM, Ho AN, Kiesel VA, Chen F, Gates CE, Paules EM, Xu R, Holt CA, Coleman MF, Hursting SD

But they also reduce inflammation, improve endothelial function, shift mitochondrial metabolism, and alter the behavior of fat cells

Incretin-based therapies and lifestyle interventions: the evolving role of registered dietitian nutritionists in obesity care