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In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary

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Weight loss through any interventionwhether pharmacological, surgical, or lifestyle-basedconsistently reduces inflammatory markers, making it difficult to isolate drug-specific effects

High dose B12 (prefer to not use cyanocobalamin) is an effective treatment for septic shock and carbon monoxide poisoning

The deficiency can lead to subtle cognitive and neurologic changes, as well as to more severe anemia and dementia