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This family of bacteria are able to metabolize primary bile acids into secondary bile acids, which then bind to TGR5 and stimulate GLP-1 secretion ( Akkermansia muciniphila significantly increases the ileal expression of Gcg and Pcsk1 , and oral glucose-stimulated plasma GLP-1 compared to mice fed the HFD alone (Yoon et al., 2021)

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This means that diverting a lot of NADPH to service other reactions would increase oxidative stress